Fig. 1

The effect sizes for susceptibility to rheumatoid arthritis correlate with the effect sizes for cardiovascular mortality in inflammatory polyarthritis in NOAR. This graph depicts the most frequent haplotypes occurring in the NOAR cohort, as defined by an allele frequency of over 12%. The x-axis shows the susceptibility to ACPA-positive RA expressed as odds ratios (see Raychaudhuri et al. [8]). The Y-axis shows cardiovascular mortality risk in inflammatory polyarthritis expressed as hazard ratios, which were derived from multi-variate cox-proportional hazard models adjusted for available cardiovascular risk factors: obesity, gender and presence of hypertension. Values are plotted on a logarithmic scale. A one-tailed p value was calculated using a linear regression model to determine the association between effect sizes (β coefficients) of susceptibility and cardiovascular mortality