Fig. 2

Mediation analysis. This figure shows acyclic graphs which depict results of mediation analysis in Table 3. A depicts hypothetical pathways and B shows pathways identified as significant from the analysis. The main proposed pathways are highlighted in bold. Alongside Table 3, it suggests some of the association between genetic risk (HLA DRB1 haplotypes) and cardiovascular mortality in inflammatory polyarthritis is independent of anti-CCP and CRP