Fig. 2

Expression of molecules associated with extracellular matrix remodeling and fibrosis in skin biopsies of SSc patients undergoing AHSCT. Mean ± standard deviation of skin sections marked by immunohistochemistry for a MMP-1, b MMP-2, c MMP-3, d MMP-9, e TIMP-1, f NF-κB p65, g α-SMA, and h TGF-β expression (% of marked area) in SSc skin biopsies. *p < 0.05. **p < 0.01. ***p < 0.001