Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still’s disease

Table 4 Associated factors with the poor treatment outcome at week 4

	Univariable analysis		Multivariable analysis (model 1)^a		Multivariable analysis (model 2)^b
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Age, per 1 year increment	1.02 (0.99–1.04)	0.259	1.00 (0.97–1.04)	0.995	1.00 (0.97–1.04)	0.839
WBC, per 1000/μl increment	1.14 (1.05–1.24)	0.003	1.16 (1.04–1.29)	0.010
NLR	1.07 (1.02–1.12)	0.006			1.06 (1.00–1.13)	0.063
Plt, per 1×10⁴/μl increment	0.97 (0.94–1.01)	0.180	0.98 (0.92–1.04)	0.457	1.01 (0.96–1.06)	0.659
Ferritin, per 1000ng/ml increment	1.05 (1.01–1.10)	0.014	1.02 (0.98–1.06)	0.450	1.01 (0.96–1.06)	0.712
LDH, per 100U/l increment	1.05 (0.98–1.12)	0.147	1.19 (0.95–1.49)	0.125	1.36 (1.02–1.81)	0.039
AST	1.00 (1.00–1.00)	0.829
mSFS	2.25 (1.18–4.29)	0.014	1.64 (0.79–3.42)	0.186	1.17 (0.50–2.78)	0.718
Modified Pouchot score	2.00 (1.37–2.90)	<0.001
Hemophagocytic syndrome	4.14 (0.97–17.6)	0.055
Severity Index	1.89 (1.27–2.81)	0.002

WBC white blood cell count, NLR neutrophil-lymphocyte ratio, Plt platelet count, LDH lactate dehydrogenase, AST aspartate transferase, mSFS modified systemic feature score, Severity index severity index of Japanese Ministry of Health, Labour and Welfare
^aAge, WBC, Plt, ferritin, LDH, and mSFS were selected as covariates of interest. Modified Pouchot score and severity index were not included in the multivariable model because these contained WBC and ferritin
^bAge, NLR, Plt, ferritin, LDH, and mSFS were selected as covariates of interest

ISSN: 1478-6362