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Table 1 Demographics, cardiovascular risk factors, and disease-related data in subjects

From: The angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis is disrupted in patients with rheumatoid arthritis

  Controls RA  
(n=246) (n=323) p
Age, years 54 ± 16 55 ± 10 0.62
Female, n (%) 162 (66) 263 (81) <0.001
BMI, kg/m2 30 ± 3 28 ± 5 <0.001
Abdominal circumference, cm 100 ± 6 97 ± 13 <0.001
Cardiovascular data    
CV risk factors, n (%)
 Current smoker 47 (19) 64 (20) 0.83
 Obesity 67 (27) 104 (32) 0.20
 Hypertension 92 (37) 101 (31) 0.13
 Diabetes mellitus 42 (17) 42 (13) 0.16
Blood pressure, mm Hg
 Systolic 139 ± 8 133 ± 19 <0.001
 Diastolic 84 ± 5 81 ± 12 0.001
Statins, n (%) 66 (27) 104 (32) 0.19
Disease-related data
CRP at time of study, mg/l 2.0 (1.1–4.6) 2.6 (1.3–6.1) 0.023
Disease duration, years   8 (4–15)  
ESR at time of study, mm/1° hour   25 (12–45)  
Rheumatoid factor, n (%)   218 (67)  
ACPA, n (%)   179 (55)  
DAS28-ESR   2.32 ± 1.19  
DAS28-PCR   2.54 ± 1.05  
SDAI   12 (6–20)  
CDAI   8 (4–14)  
HAQ   0.750 (0.250–1.250)  
Current drugs, n (%)
 Prednisone   123 (38)  
 Prednisone doses, mg/day   5 (3–5)  
 NSAIDs   154 (48)  
 DMARDs   277 (86)  
 Methotrexate   238 (74)  
 Leflunomide   72 (22)  
 Hydroxychloroquine   37 (11)  
 Sulfasalazine   25 (8)  
 Anti-TNF therapy   68 (21)  
 Tocilizumab   17 (5)  
 Rituximab   6 (2)  
 Abatacept   6 (2)  
 JAK inhibitors   7 (2)  
Historical disease-related data    
History of extraarticular manifestations, n (%)   24 (7)  
Erosions, n (%)   113 (35)  
CRP at time of disease diagnosis, mg/l   6.4 (2.5–17.1)  
CRP >3 at time of disease diagnosis, n (%)   152 (47)  
ESR at disease diagnosis, mm/1° hour   31 ± 19  
Subclinical atherosclerosis    
Carotid IMT, microns   698 ± 137  
Carotid plaques, n (%)   124 (38)  
  1. Data represent means ± SD or median (IQR) when data were not normally distributed
  2. CV cardiovascular, LDL low-density lipoprotein, HDL high-density lipoprotein, CRP C-reactive protein, NSAID nonsteroidal anti-inflammatory drugs, DMARD disease-modifying antirheumatic drug, TNF tumor necrosis factor, Obesity, ESR erythrocyte sedimentation rate, BMI body mass index, DAS28 Disease Activity Score in 28 joints, ACPA anti-citrullinated protein antibodies, CDAI Clinical Disease Activity Index, SDAI Simple Disease Activity Index, HAQ Health Assessment Questionnaire