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Table 2 Multivariable analysis of the differences in lipid profile and angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase serum levels between RA patients and controls

From: The angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis is disrupted in patients with rheumatoid arthritis

  Controls (n=246) RA patients (n=323) Univariable model Model #1 beta coef. (95% CI), p Model #2 beta coef. (95% CI), p
Lipid profile    p   
Cholesterol, mg/dl 198 ± 45 203 ± 38 0.12 5 (−2–12), 0.18 14 (623), 0.001
Triglycerides, mg/dl 144 ± 68 149 ± 88 0.44   
HDL cholesterol, mg/dl 52 ± 15 56 ± 15 0.001 1 (−1–4), 0.29  
LDL cholesterol, mg/dl 117 ± 37 117 ± 33 0.96   
LDL:HDL cholesterol ratio 2.38 ± 0.89 2.25 ± 0.94 0.10 0.01 (−0.15–0.17), 0.95  
Non-HDL cholesterol, mg/dl 146 ± 40 147 ± 38 0.72   
Lipoprotein (a), mg/dl 38 (14–101) 33 (11–111) 0.99   
Apolipoprotein A1, mg/dl 174 ± 39 170 ± 29 0.12 −9 (−15 to −4), 0.001 −9 (−16 to −3), 0.006
Apolipoprotein B, mg/dl 104 ± 29 107 ± 47 0.38   
Apo B:Apo A ratio 0.61 ± 0.18 0.64 ± 0.25 0.097 0.05 (0.01–0.09), 0.008
Atherogenic index 4.01 ± 1.12 3.88 ± 1.33 0.22   
Angiopoietin-like protein 4, ng/ml 73 (47–121) 151 (90–290) <0.001 215 (147–284), <0.001 295 (213–376), <0.001
Apolipoprotein C3, mg/dl 6.2 ± 5.6 8.8 ± 5.2 <0.001 2.9 (1.9–3.9), <0.001 2.9 (1.7–4.0), <0.001
Lipoprotein lipase, ng/ml 230 (183–328) 99 (60–156) <0.001 −121 (−160 to −82), <0.001 −174 (−213 to −135), <0.001
  1. Data represent means ± standard deviation or median (interquartile range) when data were not normally distributed
  2. HDL high-density lipoprotein, LDL low-density lipoprotein
  3. Model #1: adjusted for sex, body mass index, abdominal circumference, hypertension, diabetes, C-reactive protein, and statins (variables with a p value < 20 difference between patients and controls)
  4. Model #2: adjusted for model #1 + rest of lipid molecules (with a p value < 0.20 in the univariate analysis) other than the one that is compared
  5. Because collinearity LDL cholesterol, LDL:HDL ratio, non-HDL cholesterol, apoB:apoA, and atherogenic index were excluded of the multivariable analyses in model 2