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Table 4 Relation of angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis to subclinical atherosclerosis in RA patients

From: The angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis is disrupted in patients with rheumatoid arthritis

  Carotid plaque cIMT, microns
Univariable   Adjusted   Univariable Adjusted
No=199 Yes=124 p OR (95% CI) p beta coef. (95% CI), p  
Age, years 51 ± 10 61 ± 8 <0.001    7 (6–8), <0.001  
Female, n (%) 175 (88) 88 (71) <0.001    −88 (−126 to –50), <0.001  
BMI, kg/m2 28 ± 5 28 ± 5 0.51    2 (−8–5), 0.14  
Abdominal circumference, cm 97 ± 14 97 ± 11 0.71    2 (1–3), 0.004  
Cardiovascular data        
CV risk factors, n (%)
 Current smoker 37 (19) 27 (22) 0.49    4 (−34–42), 0.84  
 Obesity 67 (34) 37 (30) 0.47    21 (−10–54), 0.18  
 Hypertension 49 (25) 52 (42) 0.001    61 (29–93), <0.001  
 Diabetes mellitus 17 (9) 25 (20) 0.003    87 (43–132), <0.001  
Blood pressure, mm Hg
 Systolic 130 ± 18 138 ± 19 0.001    2 (1–3), <0.001  
 Diastolic 81 ± 12 83 ± 11 0.077    1 (0.3), 0.061  
Statins, n (%) 46 (23) 57 (46) <0.001    51 (20–83), 0.002  
Lipid profile        
Cholesterol, mg/dl 205 ± 37 201 ± 39 0.42    0.2 (−0.2–0.6), 0.24  
Triglycerides, mg/dl 138 ± 82 168 ± 93 0.003    0.1 (−0.0–0.3), 0.13  
HDL cholesterol, mg/dl 57 ± 15 55 ± 16 0.50    −0.7 (−1.7–0.3), 0.17  
LDL cholesterol, mg/dl 121 ± 32 112 ± 35 0.030    0.3 (−0.2–0.7), 0.24  
LDL:HDL cholesterol ratio 2.30 ± 0.97 2.18 ± 0.90 0.24    12 (−4–28), 0.14  
Non-HDL cholesterol, mg/dl 148 ± 39 146 ± 38 0.61    0.3 (−0.0–0.7), 0.085  
Lipoprotein (a), mg/dl 29 (10–87) 38 (14–132) 0.018    0.0 (−0.2–0.2), 0.74  
Apolipoprotein A1, mg/dl 170 ± 29 171 ± 30 0.70    0.0 (−0.5–0.5), 0.98  
Apolipoprotein B, mg/dl 108 ± 57 104 ± 24 0.51    0.2 (−0.2–0.5), 0.35  
Apo B:Apo A ratio 0.65 ± 0.28 0.63 ± 0.17 0.42    36 (−25–97), 0.25  
Atherogenic index 3.87 ± 1.38 3.89 ± 1.25 0.92    9 (−3–20), 0.13  
Axis        
Angiopoietin-like protein 4, ng/ml 143 (85–281) 161 (104–451) 0.15 1.00 (0.99–1.00) 0.14 0.07 (0.03–0.10), <0.001 0.05 (0.02–0.08), <0.001
Apolipoprotein C3, mg/dl 8.3 ± 4.7 9.8 ± 5.9 0.028 1.03 (0.97–1.09) 0.41 2.9 (−0.3–6.2), 0.077 0.4 (−2.6–3.4), 0.78
Lipoprotein lipase, ng/ml 91 (53–149) 108 (76–166) 0.34    0.03 (−0.03–0.09), 0.26 0.01 (−0.04–0.6), 0.73
  1. BMI body mass index, CV cardiovascular, HDL high-density lipoprotein, LDL low-density lipoprotein, OR odds ratio, cIMT carotid intima-media thickness
  2. Carotid plaque and cIMT are dependent variables. Multivariable logistic regression—odds ratios—is adjusted for age, gender, hypertension, diabetes mellitus, statins, triglycerides, LDL cholesterol and lipoprotein (a). Multivariable linear regression is adjusted for age, gender, abdominal circumference, hypertension, diabetes mellitus, statins, triglycerides, and HDL cholesterol
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Arthritis Research & Therapy

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