Assessing the diagnostic value of a potential screening tool for detecting early interstitial lung disease at the onset of inflammatory rheumatic diseases

Table 4 Area under the curves (AUC), sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR−) for different cutoffs in the detection of lung involvement in IRD patients by different examinations in the ILD group

Diagnostic procedure	Parameter	AUC (95% CI; P)	Cutoff	Sensitivity	Specificity	LR+	LR−
PFT	DLCO	0.772 (0.690–0.855; P < 0.001)	< 80%	83.6%	45.8%	1.54	0.36
	DLCO	0.772 (0.690–0.855; P < 0.001)	< 70%	67.2%	76.3%	2.84	0.43
	TLC	0.707 (0.610–0.803; P < 0.001)	< 80%	32.1%	94.6%	5.94	0.72
	TLC	0.707 (0.610–0.803; P < 0.001)	< 70%	23.2%	100.0%	> 100	0.77
	TLCO	0.686 (0.591–0.781; P = 0.001)	< 80%	57.6%	67.8%	1.79	0.63
	TLCO	0.686 (0.591–0.781; P = 0.001)	< 70%	32.2%	84.7%	2.10	0.80
	FVC	0.648 (0.548–0.747; P = 0.005)	< 80%	47.5%	78.7%	2.23	0.67
	FVC	0.648 (0.548–0.747; P = 0.005)	< 70%	32.2%	91.8%	3.93	0.74
	FEV₁	0.629 (0.526–0.732; P = 0.015)	< 80%	49.2%	82.0%	2.73	0.62
	FEV₁	0.629 (0.526–0.732; P = 0.015)	< 70%	33.9%	91.1%	3.81	0.73
Chest X-ray				64.2%	73.6%	2.43	0.49
HRCT				100.0%	55.3%	2.24	< 0.01

DLCO Diffusing capacity for carbon monoxide, FEV₁ Forced expiratory volume in 1 s, FVC Forced vital capacity, HRCT High-resolution computed tomography, LR Likelihood ratio, PFT Pulmonary function tests, TLC Total lung capacity, TLCO Transfer factor of the lung for carbon monoxide

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