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Table 4 Area under the curves (AUC), sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR−) for different cutoffs in the detection of lung involvement in IRD patients by different examinations in the ILD group

From: Assessing the diagnostic value of a potential screening tool for detecting early interstitial lung disease at the onset of inflammatory rheumatic diseases

Diagnostic procedure Parameter AUC (95% CI; P) Cutoff Sensitivity Specificity LR+ LR−
PFT DLCO 0.772 (0.690–0.855; P < 0.001) < 80% 83.6% 45.8% 1.54 0.36
< 70% 67.2% 76.3% 2.84 0.43
TLC 0.707 (0.610–0.803; P < 0.001) < 80% 32.1% 94.6% 5.94 0.72
< 70% 23.2% 100.0% > 100 0.77
TLCO 0.686 (0.591–0.781; P = 0.001) < 80% 57.6% 67.8% 1.79 0.63
< 70% 32.2% 84.7% 2.10 0.80
FVC 0.648 (0.548–0.747; P = 0.005) < 80% 47.5% 78.7% 2.23 0.67
< 70% 32.2% 91.8% 3.93 0.74
FEV1 0.629 (0.526–0.732; P = 0.015) < 80% 49.2% 82.0% 2.73 0.62
< 70% 33.9% 91.1% 3.81 0.73
Chest X-ray 64.2% 73.6% 2.43 0.49
HRCT 100.0% 55.3% 2.24 < 0.01
  1. DLCO Diffusing capacity for carbon monoxide, FEV1 Forced expiratory volume in 1 s, FVC Forced vital capacity, HRCT High-resolution computed tomography, LR Likelihood ratio, PFT Pulmonary function tests, TLC Total lung capacity, TLCO Transfer factor of the lung for carbon monoxide