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Table 5 Sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR−) for different combinations and cutoffs of diagnostic procedures in the detection of lung involvement in IRD patients with ILD

From: Assessing the diagnostic value of a potential screening tool for detecting early interstitial lung disease at the onset of inflammatory rheumatic diseases

Diagnostic procedure Parameter Cutoff Sensitivity Specificity LR+ LR−
Combination of PFT and chest X-ray DLCO and/or chest X-ray < 80% 95.2% 38.7% 1.55 0.12
< 70% 88.7% 64.5% 2.50 0.18
TLC and/or chest X-ray < 80% 69.4% 73.8% 2.65 0.41
< 70% 64.5% 77.0% 2.80 0.46
TLCO and/or chest X-ray < 80% 78.7% 58.1% 1.88 0.37
< 70% 68.9% 69.4% 2.25 0.45
FVC and/or chest X-ray < 80% 80.6% 66.1% 2.38 0.29
< 70% 71.0% 74.2% 2.75 0.39
FEV1 and/or chest X-ray < 80% 80.6% 66.1% 2.38 0.29
< 70% 71.0% 74.2% 2.75 0.39
Combination of PFT and HRCT DLCO and HRCT < 80% 83.6% 83.1% 4.95 0.20
< 70% 67.2% 88.1% 5.65 0.37
TLC and HRCT < 80% 32.1% 98.2% 17.83 0.69
< 70% 23.2% 100.0% > 100 0.77
TLCO and HRCT < 80% 57.6% 81.4% 3.10 0.52
< 70% 32.2% 91.5% 3.79 0.74
FVC and HRCT < 80% 47.5% 93.4% 7.20 0.56
< 70% 32.2% 95.1% 6.57 0.71
FEV1 and HRCT < 80% 50.8% 93.4% 7.70 0.53
< 70% 33.9% 95.1% 6.92 0.70
Combination of the following:
1. PFT and chest X-ray
2. HRCT
1. DLCO and/or chest X-ray
2. HRCT
< 80% 95.2% 77.4% 4.21 0.06
  1. DLCO Diffusing capacity for carbon monoxide, FEV1 Forced expiratory volume in 1 s, FVC Forced vital capacity, HRCT High-resolution computed tomography, LR Likelihood ratio, PFT Pulmonary function tests, TLC Total lung capacity, TLCO Transfer factor of the lung for carbon monoxide