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Table 5 Sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR−) for different combinations and cutoffs of diagnostic procedures in the detection of lung involvement in IRD patients with ILD

From: Assessing the diagnostic value of a potential screening tool for detecting early interstitial lung disease at the onset of inflammatory rheumatic diseases

Diagnostic procedure

Parameter

Cutoff

Sensitivity

Specificity

LR+

LR−

Combination of PFT and chest X-ray

DLCO and/or chest X-ray

< 80%

95.2%

38.7%

1.55

0.12

< 70%

88.7%

64.5%

2.50

0.18

TLC and/or chest X-ray

< 80%

69.4%

73.8%

2.65

0.41

< 70%

64.5%

77.0%

2.80

0.46

TLCO and/or chest X-ray

< 80%

78.7%

58.1%

1.88

0.37

< 70%

68.9%

69.4%

2.25

0.45

FVC and/or chest X-ray

< 80%

80.6%

66.1%

2.38

0.29

< 70%

71.0%

74.2%

2.75

0.39

FEV1 and/or chest X-ray

< 80%

80.6%

66.1%

2.38

0.29

< 70%

71.0%

74.2%

2.75

0.39

Combination of PFT and HRCT

DLCO and HRCT

< 80%

83.6%

83.1%

4.95

0.20

< 70%

67.2%

88.1%

5.65

0.37

TLC and HRCT

< 80%

32.1%

98.2%

17.83

0.69

< 70%

23.2%

100.0%

> 100

0.77

TLCO and HRCT

< 80%

57.6%

81.4%

3.10

0.52

< 70%

32.2%

91.5%

3.79

0.74

FVC and HRCT

< 80%

47.5%

93.4%

7.20

0.56

< 70%

32.2%

95.1%

6.57

0.71

FEV1 and HRCT

< 80%

50.8%

93.4%

7.70

0.53

< 70%

33.9%

95.1%

6.92

0.70

Combination of the following:

1. PFT and chest X-ray

2. HRCT

1. DLCO and/or chest X-ray

2. HRCT

< 80%

95.2%

77.4%

4.21

0.06

  1. DLCO Diffusing capacity for carbon monoxide, FEV1 Forced expiratory volume in 1 s, FVC Forced vital capacity, HRCT High-resolution computed tomography, LR Likelihood ratio, PFT Pulmonary function tests, TLC Total lung capacity, TLCO Transfer factor of the lung for carbon monoxide