Fig. 2From: The role of endothelin and RAS/ERK signaling in immunopathogenesis-related fibrosis in patients with systemic sclerosis: an updated review with therapeutic implicationsSchematic representation of a model for the signaling pathway involved in ET-1, TGF-β and IL-6/Ras-induced ERK1/2 activation, thus increasing fibrosis produce in systemic sclerosis fibroblasts. Salirasib is a synthetic small molecule that is able to inhibit all Ras formsBack to article page