Fig. 1

Fluorescence optical imaging illustrations in phase 1. A Baseline visit. FOI findings with clinical active RA. Increased signal intensities as a sign of active inflammation in P1. High signal intensities (FOIAS grade 3) in PIP5 of the right hand, moderate signal intensities (FOIAS grade 2) in both wrists and PIP4 of the right and PIP5 of the left hand. B After 52 weeks of CZP treatment; no increased signal intensities are detectable