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Table 1 Comparisons of the demographic, clinical, and laboratory features between the RA-ILD and the RA-non-ILD group

From: Identification of biomarkers by machine learning classifiers to assist diagnose rheumatoid arthritis-associated interstitial lung disease

 

RA-ILD (n = 75)

RA-non-ILD (n = 78)

P

Demographic parameters

 Age (years)

62.84 ± 8.71

45.15 ± 13.31

 < 0.001

 Female/male, n

45/30

58/20

0.058

 Smoker, n (%)

16 (21.33)

9 (11.54)

0.101

Clinical parameters

 TJC

8.00 (2.00, 23.00)

5.00 (2.00, 14.25)

0.177

 SJC

2.00 (0.00, 8.00)

2.00 (0.00, 8.00)

0.338

 DAS28 (ESR)

5.59 (4.01, 6.56)

5.01 (3.50, 6.25)

0.162

 Disease duration (years)

5 (0.75, 16.00)

3.00 (1.00, 10.00)

0.280

Laboratory parameters

 WBC (*109/L)

7.36 (6.11, 8.47)

6.16 (5.26, 7.75)

0.003

 RBC (*1012/L)

4.25 ± 0.47

4.25 ± 0.47

0.970

 Hb (g/L)

123.39 ± 16.18

121.00 ± 16.88

0.373

 PLT (*109/L)

248.00 (195.00, 330.00)

294.00 (221.5, 347.25)

0.154

 LYMPH (*109/L)

1.68 (1.32, 2.38)

1.57 (1.28, 1.85)

0.117

 NEUT (*109/L)

4.77 (3.76, 6.17)

3.88 (3.29, 5.40)

0.017

 ALT (U/L)

14.60 (11.13, 18.23)

13.90 (9.75, 21.45)

0.677

 AST (U/L)

17.35 (14.50, 21.80)

16.80 (13.40, 20.00)

0.125

 TP (g/L)

67.78 ± 7.41

68.55 ± 6.00

0.485

 ALB (g/L)

35.61 ± 4.80

38.11 ± 4.88

0.002

 GLO (g/L)

32.17 ± 7.01

30.51 ± 5.57

0.111

 ESR (mm/h)

57.00 (30.00, 95.00)

36.00 (18.00, 67.00)

0.003

 CRP (mg/L)

26.00 (9.04, 69.13)

11.70 (3.08, 38.00)

0.003

 IgG (g/L)

12.75 (10.10, 15.93)

12.30 (11.03, 15.40)

0.852

 IgA (g/L)

3.34 ± 1.22

3.12 ± 1.20

0.307

 IgM (g/L)

1.42 (0.98, 1.82)

1.33 (0.99, 2.03)

0.574

 RF ( +), n (%)

63 (84.00)

56 (71.79)

0.069

 Anti-CCP ( +), n (%)

59 (78.67)

53 (67.95)

0.135

  1. All data are reported as the numbers, mean ± SD or medians (IQR). The categorical variables are compared by chi-squared, Mann–Whitney U test, or independent sample T test and were used for continuous variables
  2. TJC, tender joint count; SJC, swollen joint count; WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; PLT, platelet count; LYMPH, lymphocyte; NEUT, neutrophile; ALT, alanine transaminase; AST, aspartate aminotransferase; TP, serum total protein; ALB, albumin; GLO, globulin; CRP, C-reactive protein; Ig, immune globulin