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Table 2 Medication use during the observation perioda

From: Unincreased risk of hospitalized infection under targeted therapies versus methotrexate in elderly patients with rheumatoid arthritis: a retrospective cohort study

  Young group (16–64, n = 9122) Elderly group (65–74, n = 7155) Older elderly group (75–, n = 6419) P-valueb
During exposure to bDMARDs/JAKIs with or without methotrexate, %
 TNF inhibitors 67.3 56.6 51.0 < 0.001
  Infliximab 12.6 6.1 2.6 < 0.001
  Etanercept 20.6 18.0 17.2 0.001
  Adalimumab 18.8 10.1 6.3 < 0.001
  Golimumab 15.4 22.3 25.5 < 0.001
  Certolizumab pegol 6.8 4.9 2.9 < 0.001
 Tocilizumab 28.0 24.9 21.0 < 0.001
 Abatacept 14.4 27.8 38.4 < 0.001
 JAKIs 6.0 7.5 7.0 0.034
  Tofacitinib 3.7 4.6 4.4 0.143
  Baricitinib 2.3 3.1 2.9 0.140
 Methotrexate or any immunosuppressive DMARD use 71.6 67.4 54.7 < 0.001
  Methotrexate 63.0 52.9 37.7 < 0.001
  Taclolimus 14.4 18.5 19.3 < 0.001
  Mizoribine 2.3 3.6 3.8 < 0.001
  Leflunomide 1.4 1.6 1.0 0.157
 Oral CS use, % 52.4 57.4 66.2 < 0.001
  Maximum dose of oral CS c≥ 10 mg/day, % 19.5 18.6 21.7 0.017
  Mean dose of oral CS c≥ 10 mg/day, % 8.8 7.7 10.3 0.001
  Mean dose of oral CS c≥ 7.5 mg/day, % 11.6 12.0 15.5 < 0.001
During exposure to MTX without a bDMARDs and with or without other csDMARDs, %
 Any immunosuppressive DMARD use 12.7 10.9 10.2 < 0.001
  Taclolimus 10.7 9.4 8.3 < 0.001
  Mizoribine 1.8 1.6 2.0 0.354
  Leflunomide 0.7 0.3 0.3 0.001
 Oral CS use, % 51.8 55.4 63.2 < 0.001
  Maximum dose of oral CS c≥ 10 mg/day, % 22.2 20.1 22.2 0.016
  Mean dose of oral CS c≥ 10 mg/day, % 12.5 9.9 12.0 < 0.001
  Mean dose of oral CS c≥ 7.5 mg/day, % 16.0 13.4 16.7 < 0.001
  1. bDMARDs Biological disease-modifying antirheumatic drugs, CS Corticosteroids, csDMARDs Conventional synthetic disease-modifying antirheumatic drugs, JAKIs Janus kinase inhibitors, TNF Tumor necrosis factor
  2. aNumbers are the percentages of the patients with the prescription of the medication under the treatment with bDMARDs/JAKIs or methotrexate
  3. bFisher’s exact test
  4. cDoses of oral corticosteroids were converted to prednisolone equivalent dose