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Table 2 Differences in peripheral circulating lymphocyte levels between HCs and pSS patients

From: Circulating Th2 cell reduction and Th1/Th2 imbalance are correlated with primary Sjogren’s syndrome-associated interstitial lung disease

 

HCs

n=80

pSS

n=142

P

Sex (female/male), n

64/16

124/18

0.146

Age (years), mean ± SD

55.91±7.17

57.90±8.94

0.090

Numbers of lymphocytes (cells/μl), median(range)

 T cells

1205.25 (646.00, 2415.00)

1175.10 (137.26, 3309.97)

0.340

 B cells

177.41 (52.93, 406.00)

213.17 (12.34, 861.13)

0.135

 CD4+T cells

655.00 (299.11, 1513.00)

627.74 (28.42, 1902.81)

0.430

 CD8+T cells

414.54 (103.00, 1084.48)

445.43 (42.26, 1779.72)

0.925

 NK cells

260.50 (52.00, 896.04)

164.00 (13.00, 1107.52)

<0.001

 Th1 cells

105.37 (2.69, 515.96)

88.83 (2.14, 1224.46)

0.247

 Th2 cells

8.27 (0.96, 27.04)

7.41 (0.28, 71.03)

0.402

 Th17 cells

6.44 (0.82, 18.18)

5.24 (0.22, 64.90)

0.264

 Treg cells

33.36 (13.26, 70.96)

27.71 (0.14, 139.28)

0.002

Proportions of lymphocytes (%), median (range)

 T cells

72.00 (50.00, 84.72)

71.95 (43.39, 92.87)

0.847

 B cells

10.60 (4.65, 23.00)

14.00 (1.76, 46.00)

0.001

 CD4+T cells

39.82 (22.86, 57.26)

39.09 (10.23, 59.26)

0.675

 CD8+T cells

24.10 (6.00, 48.45)

25.00 (8.73, 62.70)

0.443

 NK cells

15.04 (3.00, 31.00)

10.34 (1.00, 39.23)

<0.001

 Th1 cells

16.25 (0.25, 49.7)

15.05 (0.32, 83.23)

0.517

 Th2 cells

1.22 (0.18, 3.93)

1.08 (0.26, 12.06)

0.773

 Th17 cells

0.92 (0.16, 2.78)

0.93 (0.20, 11.02)

0.689

 Treg cells

5.13 (2.06, 8.28)

4.26 (1, 18.99)

<0.001

 CD4+T/CD8+T

1.64 (0.48, 6.38)

1.48 (0.22, 6.14)

0.335

 Th1/Th2

12.93 (0.62, 204)

12.06 (0.15, 121.42)

0.921

 Th17/Treg

0.17 (0.03, 0.79)

0.21 (0.02, 2.06)

0.217

  1. NK natural killer, Th helper T, Treg regulatory T, HCs healthy controls, pSS primary Sjogren’s syndrome