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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Peripheral blood CD4posCD25posFoxP3pos cells and inflammatory cytokines as biomarkers of response in rheumatoid arthritis patients treated with CTLA4-Ig

Fig. 4

AE Baseline inflammatory and peripheral blood CD4pos subpopulations associated with remission achievement under CTLA4-Ig treatment in b-DMARDs naive RA. A Rate of naive to b-DMARDs RA achieving DAS remission at 6 months of treatment with CTLA4-Ig based on pre-treatment IL-6 serum levels. B Kaplan–Meier survival curve of naive to b-DMARDs RA achieving DAS remission at 6 months of treatment with CTLA4-Ig based on pre-treatment IL-6 serum levels. C Spearman correlation test between composite disease activity indices (i.e., DAS and CDAI, respectively) and peripheral blood CD4posCD25posFoxP3pos cell rate in early naive to b-DMARDs RA at 6 months of treatment with CTLA4-Ig. D Rate of early naive to b-DMARDs RA achieving DAS remission at 6 months of treatment with CTLA4-Ig based on pre-treatment CD4posCD25posFoxP3pos cells rate; p value was calculated using the chi-square test. E Rate of naive to b-DMARDs RA achieving DAS remission at 6 months of treatment with CTLA4-Ig based on pre-treatment IL-6 serum levels and/or CD4posCD25posFoxP3pos cell rate. p values were calculated using the chi-square test; RA, rheumatoid arthritis; DAS, Disease Activity Score; CDAI, Composite Disease Activity Index; CD, cluster designation; b-DMARDs, biologic disease-modifying anti-rheumatic drugs

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