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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Tissue catabolism and donor-specific dexamethasone response in a human osteochondral model of post-traumatic osteoarthritis

Fig. 3

Effects of disease on cartilage tissue and biomarkers of bone homeostasis. A. To compare changes in the tissue proteome with IC treatment to the behavior of those same proteins in the media, the log2 fold changes (FC) of proteins with a significant effect with injury and cytokine (IC) treatment versus control (N) in cartilage tissue were plotted against their media log2 FC of IC/N. Colors represent significance and direction of effect in media. B. Log2 fold change of media levels for selected biomarkers of bone health across all treatment conditions. N, no treatment; D, Dex alone treatment; IC, injury and cytokine treatment; ICD, injury, cytokines, and Dex; ALPL, alkaline phosphatase; OMD, osteomodulin; SPARC, osteonectin; SPPI, osteopontin; SOST, sclerostin; TNFRSF11B, osteoprotegerin. *: p < 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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