Fig. 4
Effects of disease and Dex on individual tryptic and semitryptic peptides from aggrecan and collagen II. Log2 fold change of injury and cytokine treatment versus control (A–D) or Dex versus control (E, F) abundances of peptides identified in aggrecan (ACAN; A, C, E) and collagen II (COL2A1l; B, D, E). Peptides identified in media (A, B, E, F) or tissue (C, D). x-axis: residue position of first amino acid for each peptide. Orange: significant (p < 0.05) increase compared to control. Blue: significant (p < 0.05) decrease compared to control. Gray: no significant change compared to control (N.S.) Positions of globular domains for aggrecan (G1, G2, G3) and collagen II N- and C-terminal regions (N-term. and C-term., respectively) are highlighted