Fig. 5

Semitryptic peptides associated with increased sGAG loss. Semitryptic peptide abundance data across all media samples were regressed against sGAG loss for each donor and treatment condition. Selected peptides from among the top 50 highest associated peptides are displayed on their corresponding position in their master protein. Gray areas represent notable domains for each protein; ACAN: globular domains; COMP: N-terminal domain, FBN1: N- and C-terminal domains; FMOD: leucine-rich repeats; LUM: leucine-rich repeats; MMP1: propeptide; MMP3: propeptide. • : Carbamidomethylation of cysteine residue