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Table 2 Biological process and molecular function enrichment for tissue proteins significantly affected by Dex/injury treatment. Proteins with a significant effect (either increased or decreased, p < 0.05) of mechanical injury and cytokine treatment versus control (IC/N), or injury, cytokines, and Dex versus injury and cytokines (ICD/IC) were analyzed with STRING protein association network analysis, and the five biological processes and molecular functions with the strongest enrichment (log10(number of observed proteins/number of expected proteins)) were selected

From: Tissue catabolism and donor-specific dexamethasone response in a human osteochondral model of post-traumatic osteoarthritis

 

Biological process

FDR

Molecular function

FDR

IC/N

 Increased

Negative regulation of plasminogen activation

0.0409

Protease binding

0.0064

Negative regulation of metallopeptidase activity

0.049

Endopeptidase inhibitor activity

0.0182

Extracellular matrix disassembly

4.33E−06

Enzyme inhibitor activity

0.0483

Collagen catabolic process

0.0033

Signaling receptor binding

7.85E−05

Regulation of cellular senescence

0.0495

Binding

0.0182

   Decreased

Hydroxylysine biosynthetic process

0.0491

Procollagen-lysine 5-dioxygenase activity

0.0042

Isocitrate metabolic process

0.0092

Procollagen-proline dioxygenase activity

0.0164

Valine metabolic process

0.0092

Peptide disulfide oxidoreductase activity

0.0042

Peptidyl-lysine hydroxylation

0.016

Racemase and epimerase activity, acting on carbohydrates and derivatives

0.0404

Positive regulation of rna polymerase ii transcription preinitiation complex assembly

0.0252

L-ascorbic acid binding

0.0011

ICD/N

 Decreased

Telomerase holoenzyme complex assembly

0.0074

Procollagen-lysine 5-dioxygenase activity

0.0075

Isocitrate metabolic process

0.00088

Proteasome-activating atpase activity

0.0075

Positive regulation of rna polymerase ii transcription preinitiation complex assembly

0.00022

Isocitrate dehydrogenase activity

0.0168

Valine metabolic process

0.0153

Procollagen-proline dioxygenase activity

0.0313

Positive regulation of establishment of protein localization to telomere

0.0032

Peptide disulfide oxidoreductase activity

0.001

  1. FDR: False discovery rate