Fig. 4

Receiver operating characteristic (ROC) analysis of metabolites for the presence of radiographic knee osteoarthritis. ROC analysis was performed to estimate the predictivity of cystine (a), uric acid (b), and tyrosine (c) for the presence of radiographic knee osteoarthritis. Cystine has the highest area under the curve value with a cutoff value of 2.23 and an odds ratio of 3.7. TPF, true-positive fraction; FPF, false-positive fraction