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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis

Fig. 5

Calpain inhibitor treatment in mouse of the bleomycin model of SSc. A C3H/He mice were subjected to either sham treatment (Control) or BLM (bleomycin model of SSc) and then treated with calpain inhibitor (PD150606; 3 mg/kg/day, i.p.) or PBS (vehicle) for 30 days. Skin and lung tissue sections where then assessed by H&E staining. Scale bars, 50 μm, magnification X200. B Skin thickness was quantified and expressed in µM. C Lung inflammatory scores were determined based on histopathological analysis as described in materials and methods. Data are mean ± SD. The test of Homogeneity of variance showed P > 0.1, AVONA test was applied. n = 7, * P < 0.05 in comparison to Sham group; # P < 0.05 in comparison to BLM + PD150606 group

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Arthritis Research & Therapy

ISSN: 1478-6362

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