Echocardiographic parameter | Total SSc population n = 20 | Variance P value | Cohort 1 SSc without PAH, n = 10 | Variance P value | Cohort 2 SSc with PAH n = 10 | Variance P value | |||
---|---|---|---|---|---|---|---|---|---|
A | B | A | B | A | B | ||||
RA area, cm2 | 18.3 ± 4.7 | 18.4 ± 5.8 | 0.66 | 16.0 ± 2.3 | 15.5 ± 2.4 | 0.37 | 20.6 ± 5.5 | 21.3 ± 6.7 | 0.24 |
RV hypertrophy yes, n (%) | 16 (80) | 16 (80) | 1 | 7 (70) | 7 (70) | 1 | 9 (90) | 9 (90) | 1 |
RVH, cm | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.79 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.85 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.73 |
RVIDD, cm | 3.0 ± 0.5 | 3.0 ± 0.5 | 0.68 | 2.7 ± 0.4 | 2.7 ± 0.4 | 1 | 3.2 ± 0.4 | 3.3 ± 0.4 | 0.66 |
Mid RVOT, cm | 3.0 ± 0.5 | 3.0 ± 0.5 | 0.46 | 2.7 ± 0.4 | 2.8 ± 0.4 | 0.04 | 3.2 ± 0.4 | 3.2 ± 0.6 | 0.71 |
Distal RVOT, cm | 2.0 ± 0.3 | 2.0 ± 0.4 | 0.55 | 2.0 ± 0.2 | 2.0 ± 0.2 | 0.78 | 2.1 ± 0.4 | 2.1 ± 0.4 | 0.61 |
RV base, cm | 4.1 ± 0.6 | 4.1 ± 0.7 | 0.62 | 3.7 ± 0.5 | 3.6 ± 0.5 | 0.43 | 4.4 ± 0.6 | 4.6 ± 0.6 | 0.12 |
RV mid, cm | 2.7 ± 0.7 | 2.7 ± 0.7 | 0.58 | 2.3 ± 0.4 | 2.3 ± 0.5 | 0.78 | 3.1 ± 0.7 | 3.1 ± 0.7 | 0.56 |
RV length, cm | 8.4 ± 1.1 | 8.6 ± 1.1 | 0.06 | 7.7 ± 0.6 | 8.0 ± 0.5 | 0.10 | 9.1 ± 1.1 | 9.3 ± 1.2 | 0.36 |
RVED area, cm2 | 21.6 ± 7.4 | 22.1 ± 7.9 | 0.37 | 17.2 ± 3.2 | 16.7 ± 2.8 | 0.61 | 26.0 ± 8.0 | 27.5 ± 7.7 | 0.25 |
RVES area, cm2 | 10.7 ± 5.3 | 11.5 ± 6.0 | 0.10 | 7.9 ± 2.6 | 8.1 ± 2.2 | 0.82 | 13.5 ± 5.9 | 14.8 ± 6.8 | 0.07 |
FAC, % | 52.1 ± 11.0 | 50.4 ± 12.5 | 0.27 | 54.2 ± 9.7 | 52.3 ± 6.9 | 0.35 | 50.0 ± 12.3 | 48.5 ± 16.6 | 0.55 |
TAPSE, cm | 2.0 ± 0.4 | 2.0 ± 0.5 | 0.61 | 2.0 ± 0.3 | 2.0 ± 0.3 | 0.26 | 2.0 ± 0.5 | 2.1 ± 0.6 | 0.13 |
S’ wave, cm/s | 12.4 ± 3.0 | 12.6 ± 2.9] | 0.54 | 14.0 ± 1.9 | 14.1 ± 1.6 | 0.63 | 10.7 ± 3.1 | 11.0 ± 3.2 | 0.72 |
RVOT VTI, cm | 13.8 ± 3.5 | 13.6 ± 3.3 | 0.77 | 13.9 ± 2.7 | 14.8 ± 2.6 | 0.18 | 13.6 ± 4.3 | 12.4 ± 3.6 | 0.02 |
RAP, mmHg | 5.5 ± 3.4 | 5.5 ± 3.4 | 1.00 | 4.0 ± 2.1 | 4.0 ± 2.1 | 1.00 | 3.6 ± 1.6 | 3.6 ± 1.6 | 1.00 |
TR V max, m/s | 2.8 ± 0.8 (n = 19) | 3.0 ± 0.9 (n = 19) | 0.03 | 2.3 ± 0.4 | 2.4 ± 0.4 | 0.03 | 3.2 ± 0.7 (n = 9) | 3.5 ± 0.8 (n = 9) | 0.14 |
RVSP, mmHg | 35.8 ± 18.4 (n = 19) | 42.2 ± 20.2 (n = 19) | 0.07 | 25.6 ± 9.3 | 28.7 ± 9.5 | 0.02 | 46.1 ± 19.2 (n = 9) | 55.7 ± 19.2 (n = 9) | 0.18 |
TAPSE:PASP, mm/mmHg | 0.7 ± 0.4 | 0.6 ± 0.4 | 0.52 | 0.9 ± 0.4 | 0.8 ± 0.5 | 0.55 | 0.5 ± 0.2 | 0.8 ± 0.5 | 0.72 |
Basal RVLSS, % | − 26.1 ± 8.0 | − 27.6 ± 9.0 | 0.20 | − 28.0 ± 5.8 | − 30.7 ± 7.2 | 0.11 | − 24.1 ± 9.7 | − 24.4 ± 9.8 | 0.86 |
Mid RVLSS, % | − 19.8 ± 5.9 | − 21.0 ± 7.5 | 0.34 | − 23.8 ± 3.1 | − 26.2 ± 5.2 | 0.15 | − 15.8 ± 5.3 | − 15.7 ± 5.6 | 0.96 |
Apical RVLSS, % | −  11.6 ± 6.0 | − 11.0 ± 5.4 | 0.64 | − 13.6 ± 7.0 | − 13.5 ± 6.6 | 0.95 | − 9.0 ± 3.9 | − 9.8 ± 4.6 | 0.46 |
Global RVLSS, % | − 19.0 ± 5.1 | − 20.1 ± 5.7 | 0.13 | − 21.7 ± 2.8 | − 23.5 ± 3.8 | 0.11 | − 16.3 ± 5.5 | − 16.7 ± 5. 4 | 0. 64 |