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Table 4 Intra- and inter-observer variability

From: Defining minimal detectable difference in echocardiographic measures of right ventricular function in systemic sclerosis

Parameter Panel A: Intra-observer variability Panel B: Inter-observer variability
Total SSc population Cohort 1 (SSc without PAH) Cohort 2 (SSc with PAH) Total SSc population Cohort 1 (SSc without PAH) Cohort 2 (SSc with PAH)
ICC (95% CI) ICC (95% CI) ICC (95% CI) ICC (95% CI) ICC (95% CI) ICC (95% CI)
TAPSE, cm 0.949 (0.903–0.973)** 0.891 (0.730–0.956) 0.970 (0.926–0.988)** 0.904 (0.871–0.949)** 0.767 (0.409–0.908)** 0.940 (0.848–0.976) **
FAC, % 0.947 (0.900–0.972)** 0.930 (0.816–0.973) 0.952 (0.880–0.981)** 0.854 (0.563–0.938)** 0.719 (0.121–0.899)** 0.891 (0.660–0.960) **
S’ wave, cm/s 0.903 (0.816–0.948)** 0.975 (0.937–0.990) 0.823 (0.552–0.930)** 0.975 (0.954–0.987)** 0.912 (0.777–0.965)** 0.980 (0.950–0.992) **
RVOT VTI, cm 0.941 (0.889–0.969)** 0.891 (0.722–0.957) 0.963 (0.900–0.986)** 0.873 (0.760–0.933)** 0.655 (0.143–0.863)* 0.940 (0.850–0.976) **
Global RVLSS, % 0.925 (0.692–0.982)** 0.967 (0.917–0.987) 0.950 (0.775–0.990)** 0.978 (0.959–0.989)** 0.938 (0.843–0.976)** 0.980 (0.949–0.992) **
RVSP, mmHg 0.994 (0.989–0.997)** 0.950 (0.950–0.992) 0.993 (0.983–0.997)** 0.990 (0.981–0.995)** 0.965 (0.912–0.986)** 0.986 (0.966–0.995) **
  1. Abbreviations: ICC intraclass coefficient correlation, CI confidence interval, TAPSE tricuspid annular plane systolic excursion, FAC fractional area change, S’ tissue Doppler-derived right ventricular systolic excursion velocity, RVOT right ventricular outflow tract, VTI velocity time integral, RVLSS right ventricular longitudinal systolic strain, RVSP right ventricular systolic pressure
  2. *P-value< 0.01
  3. **P-value< 0.001