Table 1 Panel of biomarkers used in the study
Biomarker | Description of the biomarker | Implication | Previously assessed in axSpA or AS |
|---|---|---|---|
C1M | MMP-2/9/13-degraded type I collagen | Interstitial matrix degradation | Yes |
C2M | MMP (multiple)-degraded type II collagen | Cartilage degradation | Yes |
T2CM | Collagenase-degraded type II collagen | Cartilage degradation | No |
C3M | MMP-9-degraded type III collagen | Interstitial matrix degradation | Yes |
C4M | MMP (multiple)-degraded type IV collagen | Primarily basal lamina disruption | Yes |
C6M | MMP-degraded type VI collagen | Microfibril degradation | Yes |
C10C | Cathepsin-K-mediated degradation of type X collagen | Chondrocyte activity | No |
COL10NC | NC1 domain of type X collagen | Chondrocyte activity | No |
PROM | MMP-cleaved prolargin | Interstitial matrix degradation | No |
VICM | Citrullinated and MMP-degraded vimentin | Inflammation | Yes |
CRPM | C-reactive protein metabolite | Inflammation | Yes |
PRO-C2 | Type II collagen N-terminal pro-peptide | Cartilage formation | Yes |
PRO-C3 | Type III collagen N-terminal pro-peptide | Fibrosis | No |
PRO-C4 | Type IV 7S domain collagen | Basement membrane formation | No |
PRO-C6 | Type VI collagen C5 domain | Fibrosis | No |