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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation

Fig. 1

Oral dextran sodium sulfate (DSS) administration elicits SpA features in SKG mice. a Experimental scheme of oral DSS administration during the experiment. Mice were given 1% DSS in their drinking water for 2 weeks, followed by regular water. Ten mice were used in each group. Weeks are indicated by w. b The body weight change in BALB/c and SKG mice over the experiment. c–f Arthritis incidence rates and scores and enthesitis incidence rates and scores were recorded every 2 weeks. Values are expressed as mean ± standard error of the mean (SEM). g Representative photographs of hind paws for the enthesitis evaluation method. h Representative haematoxylin and eosin-stained sections of the peripheral enthesis (Achilles tendon) and the axial enthesis (caudal vertebrae). Only DSS-treated SKG mice showed marked cell infiltration around the Achilles tendon and plantar aponeurosis (arrows), and slight cell infiltration around but not inside the annulus fibrosus of the intervertebral disk (arrows). Scale bar = 200μm. Statistical analyses were performed by using the Mann-Whitney U test (*P <0.05)

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Arthritis Research & Therapy

ISSN: 1478-6362

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