Fig. 3From: Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activationThe antibiotics, MEPM and VCM, but not the anti-fungal agent AMPH-B, ameliorate DSS-induced peripheral SpA of SKG mice. a Experimental scheme of mouse treatment with oral antibiotics (MEPM (1 g/L)+VCM (0.5 g/L)) or the anti-fungal agent (AMPH-B (0.3 g/L)) and DSS. Agents were administered in their drinking water with 6% DMSO for 1 week, followed by regular water for 1 week. Then, 1% DSS was administered in their drinking water for 2 weeks, followed by regular water. Ten mice were used in each group. b The body weight change in each group over the experiment. c–f Arthritis incidence rates and scores, enthesitis incidence rates and scores were recorded every 2 weeks. Values are the mean ± standard error of the mean (SEM). g, h FCM analysis of IFN-γ (g) and IL-17A (h) positivity of splenic CD4+ T cells in SKG mice administered with DMSO and DMSO plus antibiotics (MEPM+VCM). Five mice per group were used. Statistical analyses were performed by using the Mann-Whitney U test (*P <0.05, **P <0.01)Back to article page