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Table 1 Baseline characteristic of MPZ group (n = 7) and IVCY group (n = 13)

From: Safety and effectiveness of mepolizumab therapy in remission induction therapy for eosinophilic granulomatosis with polyangiitis: a retrospective study

 

MPZ group (n = 7)

IVCY group (n = 13)

P value*

First case/recurrence case, n (%)

6 (85.7)/1 (14.3)

12 (92.3)/1 (7.7)

1.0000

Male/female

3/4

4/9

0.6514

Age

74.0 (63.0, 83.0)

60.0 (56.0, 76.5)

0.2042

Disease duration (months)

0 (0, 1)

0 (0, 0)

0.5327

Concomitant CS dose (PSL mg/day)

50.0 (50.0, 70.0)

60.0 (40.0, 65.0)

0.9362

BVAS

17.0 (14.0, 24.0)

17.0 (13.5, 22.5)

0.9051

BVAS items

 General

6 (85.7)

11 (84.6)

1.0000

 Cutaneous

5 (71.4)

9 (69.2)

1.0000

 ENT

5 (71.4)

7 (53.8)

0.6424

 Cardiomyopathy

1 (14.3)

2 (15.4)

1.0000

 Chest

5 (71.4)

8 (61.5)

1.0000

 Abdominal

1 (14.3)

1 (7.7)

1.0000

 Renal

2 (28.6)

3 (23.1)

1.0000

 Sensory neuropathy

5 (71.4)

12 (92.3)

0.2702

 Motor neuropathy

2 (28.6)

6 (46.2)

0.6424

 ANCA positive status, n (%)

2 (28.6)

2 (15.4)

0.5868

 White blood cell count (/μL)

15,200 (12,500, 25,500)

16,600 (14,650, 21,550)

0.4511

 Absolute eosinophil count (/μL)

5760 (2475, 15,478)

7434 (1881, 11,273)

0.7214

 CRP (mg/dL)

3.72 (0.80, 10.1)

8.50 (1.20, 13.9)

0.4054

 ESR (mm/h)

44.0 (33.0, 78.0)

52.0 (23.0, 79.0)

0.8740

 IgE (IU/mL)

997 (253, 1971)

1112 (436.5, 3586.5)

0.5006

  1. Data are shown by median [quartile] or n (%). P values were determined by Fisher’s exact test or the Wilcoxon rank-sum test
  2. MPZ mepolizumab, IVCY intravenous cyclophosphamide, CS corticosteroid (prednisolone or equivalent), BVAS Birmingham Vasculitis Activity Score, ENT ear, nose, and throat
  3. *P < 0.05: MPZ group (n = 7) vs. IVCY group (n = 13)