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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production

Fig. 4

Sustained inhibition of TNF in THP-1 cells continually exposed to CC-99677. Effect of continuous inhibition of MK2i (CC-99677) or p38i (BMS-582949, BIRB-796, SCIO-794) on TNF secretion in LPS-stimulated THP-1 cells. Cells were treated with 0.1 or 1 μM CC-99677 or 1 μM p38 inhibitors for 23 h and then stimulated with LPS for 24 h. TNF secreted into the culture media was determined using magnetic beads. Data are mean (SD). LPS, lipopolysaccharide; MK2i, mitogen-activated protein kinase-activated protein kinase-2 inhibitor; p38i, p38 inhibitor; SD, standard deviation; TNF, tumor necrosis factor

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Arthritis Research & Therapy

ISSN: 1478-6362

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