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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain

Fig. 4

Current-clamp analysis of AAV6-3.2iPA2 transduction on PSN excitability (male). Representative AP traces elicited by 250 ms depolarizing current of 200 pA (A) and 500 pA (B) (same cells) from rest membrane potential (RMP) were recorded on PSNs dissociated from the rats of saline, MIA, and GFP-expressing neurons in MIA rats treated with AAV6-3.2NP or AAV6-3.2iPA2, as indicated. Comparison of responses (number of APs evoked by a 250-ms stimulus) for the PSNs in different groups across a range of step current injections from 100 to 500 pA (C); ***p < 0.001, two-way ANOVA of main effects of the groups with Bonferroni post hoc. Scatter plots with bars show analyses of the RMP (D), rheobases (E), and AP numbers evoked by input current at 250 pA (F) and 500 pA (F1) from RMP, respectively. The number in each group is the number of analyzed neurons per group. ** and *** denote p < 0.01 and < 0.001, respectively. One-way ANOVA and Turkey post hoc

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