Fig. 1From: A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label studyPre-infusion serum urate levels during the methotrexate run-in (4 weeks) and pegloticase + methotrexate treatment (up to 52 weeks) periods. In the 3 non-responders, serum urate (SU) increases above 6 mg/dL were noted at weeks 2 and 4, weeks 4 and 6, and weeks 8 and 10. Data points represent the mean values, and error bars represent standard error (includes patients on treatment, values below the lower limit of detection were set to 0). SU, serum urateBack to article page