Table 2 Cell subset frequencies in BS patients and in healthy controls
Parent population | Subset | BS patients (n = 23) | Healthy controls (n = 28) | p-value |
|---|---|---|---|---|
Lymphocyte | CD4+ T cells | 36.5 ± 10.8% | 37.4 ± 7.0% | 0.80 |
Naïve CD4+ T cells | 16.8 ± 8.6% | 17.7 ± 6.7% | 0.55 | |
Memory CD4+ T cells | 16.3 ± 7.3% | 15.8 ± 5.0% | 0.90 | |
CD8+ T cells | 16.7% ± 7.0% | 14.0 ± 5.0% | 0.13 | |
Naïve CD8+ T cells | 9.1 ± 5.4% | 8.4 ± 4.7% | 0.86 | |
Memory CD8+ T cells | 7.6 ± 4.4% | 5.7 ± 2.3% | 0.19 | |
B cells | 11.3 ± 6.7% | 10.8 ± 3.8% | 0.94 | |
Natural killer cells | 12.5 ± 10.8% | 11.9 ± 6.5% | 0.45 | |
B cells | Naïve B cells | 69.6 ± 21.5% | 73.2 ± 8.6% | 0.60 |
Unswitched memory B cells | 7.9 ± 8.1% | 7.3 ± 3.5% | 0.19 | |
Switched memory B cells | 16.0 ± 12.4% | 14.3 ± 5.4% | 0.65 | |
Plasmablasts | 1.7 ± 2.6% | 1.1 ± 1.0% | 0.86 | |
Double negative B cells | 3.7 ± 2.6% | 3.4 ± 1.6% | 0.79 | |
CD4+ T cells | Th1 cells | 9.2 ± 5.1% | 13.1 ± 5.4% | 0.003 |
Th2 cells | 11.7 ± 5.5% | 9.7 ± 4.6% | 0.11 | |
Th17 cells | 9.5 ± 4.9% | 5.4 ± 2.4% | < 0.0001 | |
T follicular helper cells | 4.9 ± 3.1% | 6.5 ± 3.4% | 0.11 | |
Fraction II effector regulatory T cells | 1.4 ± 0.5% | 1.3 ± 0.4% | 0.34 | |
Lymphocyte and monocyte gate | Monocytes | 18.6 ± 9.9% | 13.4 ± 6.5% | 0.06 |
CD16+ monocytes | 1.6 ± 1.1% | 1.4 ± 0.9% | 0.66 | |
CD16− monocytes | 17.0 ± 9.1% | 11.9 ± 6.1% | 0.06 | |
Dendritic cells | 0.7 ± 0.3% | 0.7 ± 0.3% | 0.60 | |
Myeloid dendritic cells | 0.5 ± 0.2% | 0.5 ± 0.2% | 0.34 | |
Plasmacytoid dendritic cells | 0.2 ± 0.1% | 0.2 ± 0.1% | 0.63 |