The MCP2 and the wrist plus two extensor compartments are the most affected and responsive joints/tendons out of the US7 score in patients with rheumatoid arthritis-an observational study

Table 3 Change after 3 and 6 months under therapy, all patients

Joint	Region	Mode	n	p-value
Joint	Region	Mode	n	Baseline to 3 months (T0-T1)	3 to 6 months (T1-T2)	Baseline to 6 months (T0-T2)
Synovitis
Wrist	Dorsal	GS	401	< 0.001^b	1.000^b	< 0.001^a
	Palmar	GS	398	0.022^b	0.770^b	< 0.001^a
	Ulnar	GS	393	< 0.001^b	1.000^b	< 0.001^a
	Dorsal	PD	354	0.002^b	1.000^b	< 0.001^a
	Palmar	PD	348	0.146^b	1.000^b	< 0.001^a
	Ulnar	PD	343	0.010^b	1.000^b	< 0.001^a
MCP2	Palmar	GS	401	0.008^b	0.574^b	< 0.001^a
	Dorsal	PD	286	0.121^b	1.000^b	< 0.001^a
	Palmar	PD	349	0.093^b	0.635^b	< 0.001^a
MCP3	Palmar	GS	397	0.004^b	1.000^b	< 0.001^a
	Dorsal	PD	283	0.424^b	1.000^b	< 0.001^a
	Palmar	PD	343	0.326^b	0.991^b	< 0.001^a
PIP2	Palmar	GS	399	0.058^b	1.000^b	< 0.001^a
	Dorsal	PD	250	0.943^b	1.000^b	< 0.001^a
	Palmar	PD	325	0.364^b	1.000^b	< 0.001^a
PIP3	Palmar	GS	397	0.030^b	1.000^b	< 0.001^a
	Dorsal	PD	253	0.799^b	1.000^b	< 0.001^a
	Palmar	PD	324	1.000^b	1.000^b	0.002^a
MTP2	Dorsal	GS	392	0.131^b	1.000^b	0.002^a
MTP2	Dorsal	PD	303	0.313^b	1.000^b	< 0.001^a
MTP5	Dorsal	GS	390	0.033^b	1.000^b	< 0.001^a
MTP5	Dorsal	PD	296	0.565^b	1.000^b	< 0.001^a
Tenosynovitis/paratenonitis
Wrist	EDC	GS	392	< 0.001^d	1.000^d	< 0.001^c
	EDC	PD	299	0.891^d	1.000^d	0.003^c
	FDS/P	GS	393	< 0.001^d	1.000^d	< 0.001^c
	FDS/P	PD	295	1.000^d	1.000^d	0.041^c
	ECU	GS	391	0.002^d	0.741^d	< 0.001^c
	ECU	PD	295	0.853^d	1.000^d	0.001^c
MCP level	ET2	GS	393	< 0.001^d	0.805^d	< 0.001^c
	ET2	PD	259	1.000^d	1.000^d	< 0.001^c
	ET3	GS	391	< 0.001^d	1.000^d	< 0.001^c
	ET3	PD	257	1.000^d	1.000^d	0.012^c
	FT2	GS	392	< 0.001^d	0.333^d	< 0.001^c
	FT2	PD	248	-	-	0.390^c
	FT3	GS	384	< 0.001^d	0.715^d	< 0.001^c
	FT3	PD	242	1.000^d	1.000^d	0.015^c

P-values depicting change of severity (grades) over time (the underlying data incl. effect sizes can be found in supplementary tables 3.1 and 3.2)
^aFriedman test, ^bDunn test as post-hoc test, ^cCochrane-Q test (GS) and Friedman test (PD) resp.; ^dMcNemar test (GS) and Dunn test (PD) as post-hoc tests resp.; GS greyscale, PD power Doppler
MCP metacarpophalangeal, PIP proximal interphalangeal, MTP metatarsophalangeal, FT/ET2 flexor/extensor tendon on MCP2 level, FT/ET3 flexor/extensor tendon on MCP3 level, FDS/P flexor digitorum superficialis/profundus tendon, EDC extensor digitorum communis tendon (extensor compartment lV), ECU extensor carpi ulnaris tendon (extensor compartment Vl)

ISSN: 1478-6362