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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk

Fig. 3

Investigation of enhancer activity at the DMR in Tc28a2 chondrocytes. Top, cartoon of vector showing DMR preceding Lucia gene. Bottom, Lucia reporter assays assessing enhancer activity in the presence of construct containing the DMR in an unmethylated or methylated state. Values were normalised to those in empty vector control (dotted horizontal line). Black dots represent individual samples (n = 6 replicates per group). Bars show the mean ± SEM. P-values calculated by unpaired t-test

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Arthritis Research & Therapy

ISSN: 1478-6362

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