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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk

Fig. 5

Transcription factors (TFs) predicted to bind at or close to DMR CpGs. A, B TF binding sites within 10bp of each DMR CpG as predicted by JASPAR, visualised in the UCSC Genome Browser (hg19). The TFs are marked by grey bars with the direction of the arrows within the boxes indicating the DNA strand the TF is predicted to bind to (arrows pointing to the left = antisense strand; arrows pointing to the right = sense strand). C Expression levels (TPM, transcripts per million) of the TFs predicted to bind at CpGs in hip cartilage RNA-sequencing data from OA (n = 10, black) and NOF (n = 6, grey) patients. The bars represent the mean and the SEM. The y-axis is a linear segmented scale with two segments

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