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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk

Fig. 6

Allelic expression imbalance (AEI) analysis of TMEM129 and SLBP. A Left, allelic (T/C) ratios in cartilage samples from OA patients heterozygous for TMEM129 transcript SNP rs2236786 (n = 21, numbers on x-axis are patient sample IDs). In each sample, the ratio of values for cDNA and DNA between the OA risk-conferring allele T and allele C was plotted; each triangle represents the mean of three technical repeats (purple, cDNA; black, DNA). Right, mean cDNA values for all samples represented as a box plot normalised to their corresponding DNA values (dotted line), with the line inside the box representing the median, the box the interquartile range, and whiskers showing the minimum and maximum values. B Left, allelic (A/G) ratios in cartilage samples from OA patients heterozygous for SLBP transcript SNP rs2247341 (n = 10). In each sample, the ratio of values for cDNA and DNA between the OA risk-conferring allele A and allele G was plotted; each triangle represents the mean of three technical repeats (orange, cDNA; black, DNA). Right, mean cDNA values for all samples represented as a box plot normalised to their corresponding DNA values, as above. P-values calculated by the Wilcoxon matched-pairs signed rank test. **** = P < 0.0001; ns = not significant (P > 0.05)

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