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Table 1 Description of presenting clinical features used in cluster analysis

From: Cluster analysis of patients with granulomatosis with polyangiitis (GPA) based on clinical presentation symptoms: a UK population-based cohort study

  Description
Eye Keratoconjunctivitis, episcleritis, scleritis, uveitis, non-infective conjunctivitis, significant proptosis without underlying infection or malignancy
ENT Deafness, blocked ear, otitis media, ear discharge, mastoiditis, sinusitis with symptoms of blocked sinus and sinus pain or deformity, purulent or bloody nasal discharge, nasal ulceration as evidenced by epistaxis, congestion, discharge or obstruction, deafness (hearing difficulty, deafness, blocked ear, deteriorating hearing without specified cause), hoarseness of voice and subglottic stenosis
Cough Any cough
Breathlessness Breathlessness, shortness of breath, dyspnoea of any severity and aetiology
Cardiac chest pain Cardiac chest pain, angina
Chest pain (not specified) Chest pain other than cardiac chest pain and angina
Chronic renal disease (CRF) Chronic renal failure, chronic renal disease (underlying cause hypertension)
Acute renal failure (ARF) Acute renal failure, raised creatinine, acute or chronic renal failure
Proteinuria/haematuria Proteinuria, haematuria (any aetiology)
Fatigue Any fatigue, lethargy, malaise, asthenia, tiredness, lassitude, general weakness
Constitutional Fever/sweats (fevers, pyrexia, rigours or night sweats without specified cause), lethargy and documented weight loss due to any cause
Musculoskeletal Myalgia (aching muscles, muscle pain, polymyalgia), arthritis (arthralgia or arthritis without specified cause)
Neuropathy Peripheral neuropathy, tingling or burning sensation of extremity
Rash Any rash or purpura
Gastrointestinal Abdominal symptoms of intestinal aetiology including abdominal pain, bleeding in stools and abdominal distension
Non-specific abdominal symptoms Diarrhoea of any aetiology, abdominal pain due to other causes and bloating