Table 2 Baseline demographic and clinical characteristics of patient clusters with GPA

Number of patients

649

426

176

47

-

Median (IQR) age, years

60.0 (49.6- 70.1)

58.5 (47.8- 67.3)

63.5 (53.7-74.2)

68.9 (57.4-79.5)

<0.001

Gender Females,n(%)

350 (53.9)

245 (57.5)

82 (46.6)

23 (48.9)

0.039

Smoking history,n(%)

293 (48.0)

186 (47.3)

86 (50.0)

21 (46.7)

0.828

 Missing

39 (6.0)

33 (7.7)

4 (2.3)

2 (4.3)

 1 (least deprived)

151 (23.3)

107 (25.1)

33 (18.8)

11 (23.4)

0.155

 2

130 (20.0)

83 (19.5)

37 (21.0)

10 (21.3)

 3

100 (15.4)

83 (19.5)

40 (22.7)

7 (14.9)

 4

100 (15.4)

63 (14.8)

28 (15.9)

9 (19.1)

 5

61 (9.4)

33 (7.7)

25 (14.2)

3 (6.4)

 Missing

107 (16.5)

57 (13.4)

13 (7.4)

7 (14.9)

Eye

120 (18.5)

58 (13.6)

46 (26.0)

16 (34.0)

< 0.001

ENT

385 (59.3)

211 (49.5)

157 (89.2)

17 (36.2)

< 0.001

Cough

317 (48.8)

150 (35.2)

135 (76.7)

32 (68.1)

< 0.001

Breathlessness

134 (20.6)

35 (8.2)

82 (46.6)

17 (36.2)

< 0.001

Cardiovascular (Chest pain/angina)

32 (4.9)

7 (1.6)

18 (10.2)

7 (14.9)

< 0.001

Chest pain (not specified)

189 (29.1)

76 (17.8)

102 (58.0)

11 (23.4)

< 0.001

CKD

95 (14.6)

22 (5.2)

35 (19.9)

38 (80.9)

< 0.001

ARF

50 (7.7)

11 (2.6)

11 (6.2)

28 (59.6)

< 0.001

Proteinuria/haematuria

49 (7.6)

25 (5.9)

8 (4.5)

16 (34.0)

< 0.001

Fatigue

137 (21.1)

53 (12.4)

68 (38.6)

16 (34.0)

< 0.001

Constitutional

36 (5.5)

11 (2.6)

21 (11.9)

4 (11.1)

< 0.001

Musculoskeletal

182 (28.0)

77 (18.1)

83 (47.2)

22 (46.8)

< 0.001

Neuropathy

42 (6.5)

20 (4.7)

20 (11.4)

2 (4.3)

0.008

Dermatological (Rash)

188 (29.0)

61 (14.3)

117 (66.5)

10 (21.3)

< 0.001

Gastrointestinal

92 (14.2)

27 (6.3)

65 (36.9)

0 (0.00)

< 0.001

Non-specific abdominal symptoms

130 (20.0)

36 (8.5)

93 (52.8)

1 (2.1)

< 0.001