Skip to main content

Table 3 Mortality and antibiotic usage in clusters of patients with GPA

From: Cluster analysis of patients with granulomatosis with polyangiitis (GPA) based on clinical presentation symptoms: a UK population-based cohort study

  Cluster 1 (n = 426) (limited disease) Cluster 2 (n = 176) (extra-renal generalised disease) Cluster 3 (n = 47) (renal predominant disease)
Mortality
 No. of deaths (%) 52 (12.2%) 37 (21%) 14 (29.8%)
 PY, median (IQR) 5.14 (2.00–8.69) 3.35 (1.05–5.75) 3.68 (1.34–7.72)
 Unadjusted HR (95% CI), p value 1 (reference) 2.33 (1.53–3.57), p < 0.001 2.95 (1.63–5.33), p < 0.001
 aHR (95% CI), p valuea 1 (reference) 1.61 (1.03–2.53), p = 0.037 1.95 (1.05–3.62), p = 0.035
Antibiotics use
 Cumulative period of use of antibiotics, in quarters of year (total number of antibiotic prescriptions) 3844 (9606) 596 (1636) 1339 (2874)
 Unadjusted HR (95% CI), p value 1 (reference) 1.64 (1.52–1.77), p < 0.001 1.15 (1.00–1.33), p = 0.04
 aHR (95% CI), p valuea 1 (reference) 1.46 (1.35–1.58), p < 0.001 1.21 (1.05–1.39), p = 0.009
  1. aAdjusted hazard ratio (aHR) was calculated after adjusting for age, sex, Townsend deprivation quintile, smoking and duration of steroid use. PY person years