Fig. 4

Boxplots of inflammation parameters with respective clinical disease activity index (CDAI) categories. Shown are calprotectin (a, d), ESR (b, e), and CRP values (c, f) in tocilizumab (TCZ)-treated RA patients (a–c) and in tumor necrosis factor alpha-inhibitor (TNFi)-treated RA (d–f) patients. Boxplots show medians with 25th and 75th percentiles; whiskers indicate minimums and maximums, respectively. *Significant differences in a Mann-Whitney U test