Samples | Method | Blockage target | Treatment | Results | Reference |
---|---|---|---|---|---|
SSc dermal and lung fibroblasts | Z-YVAD (OMe)-FMK | Caspase-1 | - | Reduced expression of collagen, α-SMA, and contractile fibers | [62] |
SSc dermal and lung fibroblasts | SiRNA of caspase-1 | Caspase-1 | - | Reduced secretion of hydroxyproline | [62] |
C57BL/6 mice-derived fibroblasts | NLRP3−/− | NLRP3 | BLM | Undetected hydroxyproline secretion | [62] |
C57BL/6 mice-derived fibroblasts | ASC−/− | ASC | BLM | Undetected hydroxyproline secretion | [62] |
C57BL/6 mice-derived fibroblasts | Z-YVAD (OMe)-FMK | Caspase-1 | BLM | Reduced secretion of hydroxyproline | [62] |
C57BL/6 mice | ASC−/− | ASC | BLM injection | Removed increased skin thickness and pulmonary fibrosis induced by BLM | [62] |
C57BL/6 mice | NLRP3−/− | NLRP3 | BLM injection | Removed increased skin thickness and pulmonary fibrosis induced by BLM | [62] |
C57BL/6 mice | Caspase-1−/− | Caspase-1 | BLM injection | Decreased neutrophils in BALF | [61] |
C57BL/6 mice | IL-18−/− | IL-18 | BLM injection | Decreased lung injury and pulmonary fibrosis | [61] |
B6×129 hybrid mice | Caspase-1−/− | Caspase-1 | BLM injection | Alleviated pulmonary fibrosis and lower lung hydroxyproline content | [61] |