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Table 1 Mechanism of NLRP3 inflammasome in SSc fibrosis

From: Role of NLRP3 inflammasome in systemic sclerosis

Samples

Method

Blockage target

Treatment

Results

Reference

SSc dermal and lung fibroblasts

Z-YVAD (OMe)-FMK

Caspase-1

-

Reduced expression of collagen, α-SMA, and contractile fibers

[62]

SSc dermal and lung fibroblasts

SiRNA of caspase-1

Caspase-1

-

Reduced secretion of hydroxyproline

[62]

C57BL/6 mice-derived fibroblasts

NLRP3−/−

NLRP3

BLM

Undetected hydroxyproline secretion

[62]

C57BL/6 mice-derived fibroblasts

ASC−/−

ASC

BLM

Undetected hydroxyproline secretion

[62]

C57BL/6 mice-derived fibroblasts

Z-YVAD (OMe)-FMK

Caspase-1

BLM

Reduced secretion of hydroxyproline

[62]

C57BL/6 mice

ASC−/−

ASC

BLM injection

Removed increased skin thickness and pulmonary fibrosis induced by BLM

[62]

C57BL/6 mice

NLRP3−/−

NLRP3

BLM injection

Removed increased skin thickness and pulmonary fibrosis induced by BLM

[62]

C57BL/6 mice

Caspase-1−/−

Caspase-1

BLM injection

Decreased neutrophils in BALF

[61]

C57BL/6 mice

IL-18−/−

IL-18

BLM injection

Decreased lung injury and pulmonary fibrosis

[61]

B6×129 hybrid mice

Caspase-1−/−

Caspase-1

BLM injection

Alleviated pulmonary fibrosis and lower lung hydroxyproline content

[61]

  1. Abbreviations: BLM bleomycin, BALF bronchoalveolar lavage fluid, SSc systemic sclerosis