Fig. 1

Mortality in mice after engraftment with patient-derived PBMC. A. Kaplan-Meier survival curve illustrating the survival difference between whole PBMC-transferred mice and mice transferred with T or B cell-depleted PBMC. B. Mice transferred with whole PBMC showed significantly higher death rates compared to mice transferred with T or B cell-depleted PBMC. Comparison of survival curves (A) and mortality rates (B) between whole PBMC-transferred mice and mice transferred with T or B cell-depleted PBMC was determined using the log-rank (Mantel-Cox) test and Fisher’s exact test, respectively. p values reflect the comparisons between mice transferred with whole PBMC and mice transferred with T or B cell-depleted PBMC. PBMC, mice transferred with whole PBMC from SSc patients, PBMC T^-/-, mice transferred with T cell-depleted PBMC from SSc patients, PBMC B^-/-, mice transferred with B cell-depleted PBMC from SSc patients