Fig. 2

Morphology of the splenic white pulp and human lymphocytes in the spleens of recipient mice. Representative micrographs of H&E-stained spleen sections and IHC-stained spleen sections for detecting human CD4⁺ T, CD20⁺ B, and CD138⁺ plasma cells. Green arrows indicate white pulps. PBMC, mice transferred with whole PBMC from SSc patients; PBMC T(-/-), mice transferred with T cell-depleted PBMC from SSc patients; PBMC B(-/-), mice transferred with B cell-depleted PBMC from SSc patients. Bars indicate 500 µm and 50 μm in HE-stained spleen sections and IHC-stained spleen sections, respectively