Fig. 3From: Both T and B cells are indispensable for the development of a PBMC transfer-induced humanized mouse model for SScProduction of human antibodies in recipient mice. Comparison of serum levels of total human IgG (A, B), anti-AT1R IgG (C, D), and anti-ETAR IgG (E, F) between mice transferred with whole PBMC from SSc patients and mice transferred with T cell-depleted (n = 6) or B cell-depleted (n = 9) PBMC. p values reflect the comparisons between mice transferred with whole PBMC and mice transferred with T or B cell-depleted PBMC. Statistical significance of comparison was determined using the Wilcoxon matched pairs test, and statistical significance of comparison in C was determined by the paired t testBack to article page