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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis

Fig. 6

Immunohistochemical analysis of MC1R in skin biopsies from patients with SSc. Representative images of immunohistochemical staining of skin biopsy from dcSSc patients. A Single staining with anti-MC1R antibody visualized by DAB substrate (brown) and counter-stained with hematoxylin (blue). Left: lower magnification (×40). Right: higher magnification (×100). Blue arrow: fibroblasts/mononuclear cells. Orange arrow: endothelial cells. B Double immunofluorescence staining with anti-MC1R antibody (green) and cell-specific markers (pink). Merged images with MC1R and each cell marker is shown. CD68: monocytes/macrophage; prolyl-4-hydroxylas β (P4Hβ): fibroblast; CD31; endothelial cells; CD66b: neutrophils. White circle: co-localized areas

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Arthritis Research & Therapy

ISSN: 1478-6362

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