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Table 4 Factors associated with the development of SLE in patients with primary ITP

From: Prognostic factors for the development of systemic lupus erythematosus in patients with immune thrombocytopenia

 

Univariate

Multivariate

OR

95% CI

P value

OR

95% CI

P value

Young agea

5.444

1.332–22.250

0.018

6.307

1.114–34.908

0.035

Female

4.333

0.530–35.422

0.17

   

BMI

0.873

0.717–1.070

0.20

   

Skin bleeding

8.419

1.034–68.533

0.046

   

Mucosa bleeding

1.250

0.247–6.330

0.79

   

Organ bleeding

14.864

3.633–60.815

 < 0.001

13.672

2.437–76.689

0.003

Platelet counts, × 109/L

0.911

0.828–1.002

0.055

   

ANA positivity (≥ 1:160)

16.500

3.984–68.341

 < 0.001

6.638

1.399–31.504

0.017

Leukopeniab

2.786

0.653–11.892

0.17

   

Neutropeniac

2.111

0.229–19.499

0.51

   

Lymphocytopeniad

4.846

1.189–19.759

0.028

   

Anemiae

10.118

2.044–50.091

0.005

   
  1. SLE Systemic lupus erythematosus, ITP Immune thrombocytopenia, BMI Body mass index, ANA Antinuclear antibody, OR Odds ratio, CI Confidence interval
  2. aYoung age = age < 40 years
  3. bLeukopenia = white blood cell count < 4000/μL
  4. cNeutropenia = absolute neutrophil count < 1500/μL
  5. dLymphocytopenia = absolute lymphocyte count < 1500/μL
  6. eAnemia = hemoglobin < 12 g/dL