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Table 2 Linear regression models examining relationships between pain intensity scores and DAS28-ESR and its components at 12 months

From: Defining the relationship between pain intensity and disease activity in patients with rheumatoid arthritis: a secondary analysis of six studies

 

Unadjusted

Adjusted

 

β (95%CI)

p-value

R2

β (95%CI)

p-value

R2

All studies (n=1,132)

 DAS28-ESR

10.71 (10.0, 11.4)

<0.001

0.423

11.5 (10.7, 12.2)

<0.001

0.534

 Patient global

0.89 (0.86, 0.92)

<0.001

0.774

0.86 (0.83, 0.89)

<0.001

0.793

 Tender joint counts

2.41 (2.20, 2.61)

<0.001

0.319

2.20 (1.98, 2.42)

<0.001

0.410

 Swollen joint counts

2.02 (1.78, 2.27)

<0.001

0.188

1.99 (1.73, 2.25)

<0.001

0.325

 ESR

0.15 (0.06, 0.23)

<0.001

0.011

0.20 (0.11, 0.29)

<0.001

0.197

Early active RA trials (n = 490)

 DAS28-ESR

11.26 (10.21, 12.31)

<0.001

0.477

10.61 (9.52, 11.71)

<0.001

0.539

 Patient global

0.86 (0.81, 0.90)

<0.001

0.737

0.82 (0.77, 0.87)

<0.001

0.759

 Tender joint counts

2.08 (1.78, 2.38)

<0.001

0.277

1.72 (1.42, 2.03)

<0.001

0.382

 Swollen joint counts

2.05 (1.78, 2.32)

<0.001

0.313

1.88 (1.61, 2.16)

<0.001

0.412

 ESR

0.12 (0.01, 0.24)

0.033

0.009

0.14 (0.03, 0.25)

0.016

0.205

Established active RA trials (n=469)

 DAS28-ESR

12.41 (11.13, 13.68)

<0.001

0.439

12.62 (11.35, 13.89)

<0.001

0.507

 Patient global

0.91 (0.87, 0.96)

<0.001

0.795

0.89 (0.84, 0.93)

<0.001

0.801

 Tender joint counts

2.75 (2.44, 3.06)

<0.001

0.391

2.65 (2.33, 2.98)

<0.001

0.426

 Swollen joint counts

2.77 (2.16, 3.39)

<0.001

0.143

2.64 (1.99, 3.28)

<0.001

0.214

 ESR

0.12 (−0.01, 0.26)

0.077

0.007

-

-

-

Remission/LDA studies (n=173)

 DAS28-ESR

10.51 (8.02, 12.99)

<0.001

0.289

10.02 (6.93, 13.11)

<0.001

0.481

 Patient global

0.94 (0.87, 1.01)

<0.001

0.792

0.91 (0.82, 1.00)

<0.001

0.859

 Tender joint counts

3.00 (1.84, 4.16)

<0.001

0.132

2.40 (1.28, 3.52)

<0.001

0.381

 Swollen joint counts

0.70 (−0.83, 2.24)

0.368

0.005

-

-

-

 ESR

0.19 (−0.10, 0.48)

0.201

0.010

-

-

-

  1. DAS28-ESR, disease activity score for 28 joints with the erythrocyte sedimentation rate; adjusted model contains the covariates age, gender, disease duration, body mass index, baseline pain VAS intensity score, baseline score for DAS28-ESR or the individual components baseline score, and treatment