Table 1 Characteristics of participants

Age^a

63.3 ± 7.2

Female (%)^b

46%

BMI (kg/m²)^a

29.4 ± 4.9

Baseline MTF osteophytes (0–18)^c

4.0 (2.0, 7.0)

Baseline LTF osteophytes (0–18)^c

4.0 (2.0, 8.0)

Baseline patellar osteophytes (0–6)^c

2.0 (2.0, 3.8)

Baseline total cartilage defects (0–24)^c

15.0 (12.0, 18.0)

Baseline total cartilage volume (cm³)^c

5.7 (4.6, 7.0)

Baseline total knee pain (0–500)^c

115.0 (66.0, 196.8)

Change in total knee pain^c

− 33.0 (− 95.0, 8.0)

Baseline weight-bearing pain (0–300)^c

79.5 (42.0, 126.0)

Change in weight-bearing pain^c

− 21.0 (− 63.0, 10.0)

Baseline non-weight-bearing pain (0–200)^c

32.0 (73.0, 74.0)

Change in non-weight-bearing pain^c

− 8.0 (− 44.0, 4.0)

Baseline knee dysfunction (0–1700)^c

412.5 (218.3, 668.0)

Change in knee dysfunction^c

− 108.5 (− 301.3, 16.3)

Baseline knee stiffness (0–200)^c

54.0 (25.0, 92.0)

Change in knee stiffness^c

− 13.5 (− 43.0, 8.8)