Table 3 Mediation by osteophytes on the associations between total cartilage volume and changes in knee symptoms
Outcomes | MTF osteophyte, β (95% CI) | P | LTF osteophyte, β (95% CI) | P | Patellar osteophyte, β (95% CI) | P |
|---|---|---|---|---|---|---|
Change in total knee pain | ||||||
 Indirect effect | − 1.64 (− 4.17, 0.25) | 0.10 | − 2.52 (− 5.24, − 0.69) | < 0.01 | − 3.16 (− 6.29, − 0.97) | < 0.01 |
 Direct effect | − 4.66 (− 14.13, 4.17) | 0.29 | − 3.79 (− 13.66, 5.77) | 0.44 | − 3.14 (− 12.55, 6.18) | 0.49 |
 Total effect | − 6.30 (− 15.81, 2.56) | 0.16 | − 6.30 (− 16.31, 3.29) | 0.19 | − 6.30 (− 15.86, 2.99) | 0.17 |
 Proportion mediated % | NA |  | NA |  | NA |  |
Change in weight-bearing pain | ||||||
 Indirect effect | − 1.04 (− 2.71, 0.13) | 0.09 | − 1.74 (− 3.49, − 0.48) | < 0.01 | − 1.93 (− 4.04, − 0.48) | < 0.01 |
 Direct effect | − 5.45 (− 12.06, 1.04) | 0.10 | − 4.75 (− 11.34, 1.31) | 0.13 | − 4.56 (− 11.03, 1.60) | 0.15 |
 Total effect | − 6.49 (− 13.45, − 0.11) | 0.04 | − 6.49 (− 13.54, − 0.33) | 0.04 | − 6.49 (− 13.18, − 0.31) | 0.04 |
 Proportion mediated % | NA |  | 27% |  | 30% |  |
Change in non-weight-bearing pain | ||||||
 Indirect effect | − 0.67 (− 1.72, 0.08) | 0.09 | − 0.96 (− 2.09, − 0.17) | 0.02 | − 1.26 (− 2.61, − 0.27) | < 0.01 |
 Direct effect | − 0.56 (− 4.73, 3.85) | 0.81 | − 0.28 (− 4.54, 3.92) | 0.88 | 0.02 (− 4.26, 4.10) | 0.99 |
 Total effect | − 1.24 (− 5.40, 2.97) | 0.59 | − 1.24 (− 5.64, 3.00) | 0.53 | − 1.24 (− 5.42, 2.85) | 0.54 |
 Proportion mediated % | NA |  | NA |  | NA |  |
Change in stiffness | ||||||
 Indirect effect | − 0.38 (− 1.32, 0.39) | 0.33 | − 1.23 (− 2.48, − 0.28) | < 0.01 | − 1.16 (− 2.57, − 0.23) | < 0.01 |
 Direct effect | − 2.56 (− 6.91, 1.97) | 0.25 | − 1.71 (− 6.07, 2.47) | 0.43 | − 1.78 (− 6.07, 2.65) | 0.45 |
 Total effect | − 2.94 (− 7.28, 1.54) | 0.19 | − 2.94 (− 7.56, 1.45) | 0.19 | − 2.94 (− 7.20, 1.40) | 0.19 |
 Proportion mediated % | NA |  | NA |  | NA |  |
Change in dysfunction | ||||||
 Indirect effect | − 4.85 (− 12.25, 0.57) | 0.08 | − 8.22 (− 17.18, − 2.17) | < 0.01 | − 7.87 (− 17.80, − 1.39) | < 0.01 |
 Direct effect | − 27.44 (− 54.13, − 1.47) | 0.04 | − 24.08 (− 49.24, 3.49) | 0.08 | − 24.42 (− 49.60, 1.95) | 0.07 |
 Total effect | − 32.29 (− 59.92, − 6.22) | 0.02 | − 32.29 (− 58.16, − 5.31) | 0.02 | − 32.29 (− 58.03, − 5.63) | 0.01 |
 Proportion mediated % | NA |  | 25% |  | 24% |  |