Fig. 2

Left ventricular diastolic function during the 2-year follow-up. E: peak early diastolic velocity, A: peak late diastolic velocity, DT: deceleration time of the E wave, lateral e′: early diastolic myocardial relaxation velocity, lateral a′: late diastolic myocardial relaxation velocity. E/A ratio calculated from the transmitral flow was in the normal range (>1) at the time of the diagnosis; however, it decreased significantly with parallel lengthening DT in the 2year follow-up period in the monophasic and the polyphasic group compared to the baseline and control group revealing diastolic dysfunction. Increasing E/e′ ratio during the follow-up period in both groups suggests elevating filling pressure and also supports the development of the diastolic dysfunction. TDI parameters confirm the above observations: lateral e′ decreased, lateral a′ increased significantly in the monophasic and polyphasic groups compared to the baseline and control groups. Additionally, LA diameter was comparable to the control and baseline in the monophasic groups; however, it was found to be significantly larger in the polyphasic group. * P<0.05 vs. control, # P<0.05 vs. baseline, & P<0.05 vs. monophasic