Fig. 1

TET3 expression in the RA synovial tissues. A Representative patterns of staining for 5mC, 5hmC, TET1/2/3 (brown). RA (n = 3), OA (n = 3). Scale bar, 50 μm. B The percentage of area with positive staining for TET1/2/3. RA (n = 3), OA (n = 3). C Representative patterns of staining for TET1/2/3 (blue) and CD55/CD68 (brown). Synovial tissues (n = 2). Scale bar, 20 μm. D Relative mRNA expression levels of TET1/2/3. RA FLS (n = 6), OA FLS (n = 6). Data are mean ± standard error of the mean (B) and the box-and-whisker plots (D). Two-tailed P values by the t-test (B). One-tailed P values by the Mann-Whitney U-test (D)